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Wainberg Lipid-lowering agents Drug HMG-CoA reductase inhibitors (lovastatin, pravastatin, simvastatin, atorvastatin) Niacin Bile acid resins (cholestyramine, colestipol) Cholesterol absorption blocker (ezetimibe) Fibrates (gemfibrozil, clofibrate, Effect on HDL good cholesterol LDL VLDL bezafibrate, fenofibrate) Hepatocytes Ac-CoA HMG-CoA Slightly Blood Effect on LDL bad cholesterol Effect on triglycerides Side effectsproblems Expensive, reversible LFTs, myositis Red, flushed face, which is by aspirin most active times to trade forex long-term use Patients hate ittastes bad and causes GI discomfort Rare LFTs Myositis, LFTs Endothelial Cells Gut LDL HMG-CoA reductase inhibitors Cholesterol Bile acids Resins R LDL IDL Gemfibrozil Niacin VLDL Lipoprotein lipase Lipid oxidation (Adapted, with permission, from Katzung BG, Trevor AJ.
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