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3 136 Maurer et al.Leventhal, L. 2 Chemical Properties and Behaviors of Acidic, Neutral, and Basic Compounds in the Small Intestine (pH 8 to 10) Compound Properties Acidic pKa 3 7 Neutral (Weakly Acidic) Basic 10 102:1 to 1:1 Some ionization, lipophilic Favorable Non-ionic:ionic ratio Acidicbasic nature Absorption 105:1 to 107:1 Proton donor, very low lipophilic Not favorable 101:1 to 103:1 Weak acid, some ionization, low lipophilicity Some absorption over length of optiohs tract the circumstances that influence chemical absorption in a therapeutic setting will not be tbe here.
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